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つくばリポジトリ (Tulips-R) >
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Developmental biology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/116818
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| Title: | Zincfingerhomeobox is required for the differentiation of serotonergicneurons in the seaurchinembryo |
| Authors: | Yaguchi, Junko
Angerer, Lynne M.
Inaba, Kazuo
Yaguch, Shunsuke
稲葉, 一男
谷口, 俊介 |
| Issue Date: | Mar-2012 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Developmental biology |
| Volume: | 363 |
| Issue: | 1 |
| Start Page: | 74 |
| End Page: | 83 |
| DOI: | 10.1016/j.ydbio.2011.12.024 |
| PMID: | 22210002 |
| Abstract: | Serotonergicneurons differentiate in the neurogenic animal plate ectoderm of the seaurchinembryo. The regulatory mechanisms that control the specification or differentiation of these neurons in the seaurchinembryo are not yet understood, although, after the genome was sequenced, many genes encoding transcription factors expressed in this region were identified. Here, we report that zincfingerhomeobox (zfhx1/z81) is expressed in serotonergic neural precursor cells, using double in situ hybridization screening with a serotonergic neural marker, tryptophan 5-hydroxylase (tph) encoding a serotonin synthase that is required for the differentiation of serotonergicneurons. zfhx1/z81 begins to be expressed at gastrula stage in individual cells in the anterior neuroectoderm, some of which also express delta. zfhx1/z81 expression gradually disappears as neural differentiation begins with tph expression. When the translation of Zfhx1/Z81 is blocked by morpholino injection, embryos express neither tph nor the neural marker synaptotagminB in cells of the animal plate, and serotonergicneurons do not differentiate. In contrast, Zfhx1/Z81 morphants do express fez, another neural precursor marker, which appears to function in the initial phase of specification/differentiation of serotonergicneurons. In addition, zfhx1/z81 is one of the targets suppressed in the animal plate by anti-neural signals such as Nodal as well as Delta-Notch. We conclude that Zfhx1/Z81 functions during the specification of individual anterior neural precursors and promotes the expression of tph and synaptotagminB, required for the differentiation of serotonergicneurons. |
| URI: | http://hdl.handle.net/2241/116818 |
| Rights: | © 2011 Elsevier Inc. NOTICE: this is the author’s version of a work that was accepted for publication in Developmental biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental biology, Volume 363, Issue 1, March 2012, DOI:10.1016/j.ydbio.2011.12.024 |
| Text Version: | author |
| Appears in Collections: | 稲葉 一男 (Inaba Kazuo)
谷口 俊介 (Yaguchi Shunsuke)
Developmental biology
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