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つくばリポジトリ (Tulips-R) >
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World journal of surgical oncology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/114427
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| Title: | Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy |
| Authors: | Todoroki, Takeshi
Kondo, Tadashi
Sugahara, Shinji
Morishita, Yukio
Mori, Kensaku
Ohno, Tadao
近藤, 匡
森下, 由紀雄
森, 健作 |
| Issue Date: | Aug-2011 |
| Publisher: | BioMed Central Ltd. |
| Journal Title: | World journal of surgical oncology |
| Volume: | 9 |
| Start Page: | 96 |
| DOI: | 10.1186/1477-7819-9-96 |
| PMID: | 21864347 |
| Abstract: | Malignant fibrous histiocytoma (MFH) is an aggressive spindle cell cancer of soft-tissue sarcoma type in the elderly, mostly affecting the extremities. Lesions > 5 cm, positive margins, and local recurrence are significant poor prognostic indicators. The strongest predictor for distant metastasis was tumor size (> 5 cm), and for overall survival, presence of local recurrence. Limb-sparing extensive tumor resection is preferred to achieve negative surgical margins. However, in some circumstances, amputation is inevitable. Recent studies demonstrated that adjuvant radiotherapy for microscopically positive surgical margins significantly improved local control and disease-free survival rates. Therefore, effective therapeutic strategies against locally relapsed high grade MFH are required to prevent distant metastasis and to achieve long-term disease-free survival. Here, we report local relapse of high grade MFH treated by successive application of autologous formalin-fixed tumor vaccination (AFTV) with limb-sparing surgery and postoperative radiotherapy. The patient is alive and well, disease-free and with no functional impairment, more than five years after treatment. |
| URI: | http://hdl.handle.net/2241/114427 |
| Rights: | © 2011 Todoroki et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Text Version: | publisher |
| Appears in Collections: | 森下 由紀雄 (Morishita Yukio)
森 健作 (Mori Kensaku)
近藤 匡 (Kondo Tadashi)
World journal of surgical oncology
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