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Journal of immunology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/102019
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| Title: | Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcR gamma chain on peritoneal macrophages |
| Authors: | Nakahashi, Chigusa
Tahara-Hanaoka, Satoko
Totsuka, Naoya
Okoshi, Yasushi
Takai, Toshiyuki
Ohkohchi, Nobuhiro
Honda, Shin-ichiro
Shibuya, Kazuko
Shibuya, Akira
田原，聡子
大越, 靖
本多, 伸一郎
渋谷, 彰
渋谷, 和子
大河内, 信弘 |
| Issue Date: | Jan-2007 |
| Publisher: | The American Association of Immunologists |
| Journal Title: | Journal of immunology |
| Volume: | 178 |
| Issue: | 2 |
| Start Page: | 765 |
| End Page: | 770 |
| Abstract: | Certain activating immune receptors expressed on myeloid cells noncovalently associate with either DAP12 or Fc epsilon RI gamma (FcR gamma chain), the ITAM-bearing transmembrane adapter proteins. An activating receptor, myeloid-associated Ig-like receptor (MAIR) II, is expressed on a subset of B cells and macrophages in the spleen and peritoneal cavity of mice and associates with DAP12 in these cells. However, we demonstrate here that cross-linking MAIR-II with mAb induced secretion of a significant amount of the inflammatory cytokines TNF-alpha and IL-6 from DAP12(-/-) as well as wild-type (WT) peritoneal macrophages. We show that MAIR-II associates with not only DAP12 but also FcR gamma chain homodimers in peritoneal macrophages. LPS enhanced the FcR gamma chain expression and FcR gamma chain-dependent cell surface expression of MAIR-II and had additive effects on MAIR-II-mediated inflammatory cytokine secretion from peritoneal macrophages. The lysine residue in the transmembrane region of MAIR-II was involved in the association with FcR-y chain as well as DAP12. Our findings present the first case of an activating receptor that uses either DAP12 or FcRC gamma chain as a signaling adapter. The FcR-y chain may provide cooperation with and/or compensation for DAP12 in MAIR-II-mediated inflammatory responses by peritoneal macrophages. |
| URI: | http://hdl.handle.net/2241/102019 |
| Rights: | © 2007 by The American Association of Immunologists |
| Text Version: | author |
| Appears in Collections: | Journal of immunology
渋谷 彰 (Shibuya Akira)
渋谷 和子 (Shibuya Kazuko)
本多 伸一郎 (Honda Shin-ichiro)
田原 聡子 (Tahara Satoko)
大越 靖 (Okoshi Yasushi)
大河内 信弘 (Ohkohchi Nobuhiro)
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