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つくばリポジトリ (Tulips-R) >
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International immunology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/102014
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| Title: | Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112) |
| Authors: | Tahara-Hanaoka, Satoko
Shibuya, Kazuko
Onoda, Yuko
Zhang, Hua
Yamazaki, Satoshi
Miyamoto, Akitomo
Honda, Shin-ichiro
Lanier, Lewis L.
Shibuya, Akira
渋谷, 彰
渋谷, 和子
田原, 聡子
本多, 伸一郎 |
| Issue Date: | Apr-2004 |
| Publisher: | Oxford University Press |
| Journal Title: | International immunology |
| Volume: | 16 |
| Issue: | 4 |
| Start Page: | 533 |
| End Page: | 538 |
| PMID: | 15039383 |
| Abstract: | CD226 (DNAM-1) is an adhesion molecule involved in NK and T cell-mediated cytotoxicity against certain tumors. Here, we have identified the human poliovirus receptor-related (PRR) family members CD155 [poliovirus receptor (PVR)] and CD112 (nectin-2/PRR-2) as the ligands for human CD226. Ectopic expression of human CD155 and/or CD112 rendered mouse BW5147 T cells more susceptible to IL-2-activated T and NK cell-mediated cytotoxicity, and killing was specifically inhibited by anti-CD226 mAb, demonstrating functional interactions of CD226 with CD155 and CD112. Although the binding affinities between soluble CD226 and CD155 or CD112 were comparable, the homophilic interaction of cell-surface CD112 may adversely affect CD226 binding to CD112. We also demonstrate that ligation of CD226 and LFA-1 with their respective ligands cooperates in triggering cytotoxicity and cytokine secretion by T and NK cells. |
| URI: | http://hdl.handle.net/2241/102014 |
| Rights: | (c) 2004 The Japanese Society for Immunology |
| Text Version: | author |
| Appears in Collections: | International immunology
渋谷 彰 (Shibuya Akira)
渋谷 和子 (Shibuya Kazuko)
本多 伸一郎 (Honda Shin-ichiro)
田原 聡子 (Tahara Satoko)
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