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FEBS letters >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/100085
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| Title: | Induction of podoplanin by transforming growth factor-β in human fibrosarcoma |
| Authors: | Suzuki, Hiroyuki
Kato, Yukinari
Kato Kaneko, Mika
Okita, Yukari
Narimatsu, Hisashi
Kato, Mitsuyasu
鈴木, 裕之
加藤, 光保 |
| Issue Date: | Jan-2008 |
| Publisher: | Elsevier |
| Journal Title: | FEBS letters |
| Volume: | 582 |
| Issue: | 2 |
| Start Page: | 341 |
| End Page: | 345 |
| DOI: | 10.1016/j.febslet.2007.12.028 |
| PMID: | 18158922 |
| Abstract: | Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells. |
| URI: | http://hdl.handle.net/2241/100085 |
| Rights: | © 2007 Federation of European Biochemical Societies |
| Text Version: | author |
| Appears in Collections: | FEBS letters
鈴木 裕之 (Suzuki Hiroyuki)
加藤 光保 (Kato Mitsuyasu)
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